Atypical non-[99mTc]Tc-MIBI avid parathyroid adenoma with a sternal brown tumor, mimicking ectopic parathyroid adenoma in planar and SPECT images: Importance of SPECT/CT acquisition

Authors

  • Ali Sadrizadeh Cardiothoracic Surgery and Transplant Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Athena Aghaee Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Hessamoddin Roustaei Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Mohammad Ali Yaghoubi Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
  • Ramin Sadeghi Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
  • Somaye Barashki Nuclear Medicine Research Center, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:

Primary hyperparathyroidism (pHPT) is defined by the excess level of parathyroid hormone (PTH). Parathyroid adenoma is responsible for about 80% of all pHPT. Parathyroid adenoma with cystic feature and atypical pathology is recognized as a rare entity. Technetium-99m methoxy isobutyl isonitrile ([99mTc]Tc-MIBI) scintigraphy has favorable detection rate for ectopic gland as well as the brown tumors. SPECT/CT plays critical role in localizing abnormal tracer uptake. Herein, we report a severely hypercalcemic patient with cystic atypical parathyroid adenoma and mediastinal uptake, which was confined to a sternal lytic lesion (suggestive of brown tumor), which highlights the importance of SPECT/CT in [99mTc]Tc-MIBI imaging.

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Journal title

volume 30  issue 1

pages  76- 79

publication date 2022-01-01

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